Vascular endothelial growth factor A as an early diagnostic marker of hemophilic arthropathy in children with severe hemophilia A

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Case-control study shows increased VEGF-A in children with severe hemophilia A, suggesting its role in arthropathy diagnostics.

VEGF-A levels were significantly higher in children with severe hemophilia A compared to controls, indicating its potential as a diagnostic marker.
A cutoff level of 116.68 for VEGF-A demonstrated 82.5% sensitivity and 85% specificity for detecting hemophilic arthropathy in children.
The study involved 80 male participants, 40 with severe hemophilia A and 40 healthy controls, assessing their serum VEGF-A levels.
Correlation was found between VEGF-A levels and joint health scores, highlighting its role in monitoring hemophilic arthropathy.

Shabana et al. (2025) studied this question.

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