Reduce the Risk of Microbial activity and Cytotoxicity by Adansonia digitata pulp extract, grown under the Semi-Arid Conditions of Sudan

Abstract Background:-Sudan is rich country for natural products like Adansonia digitata is locally name Gongolase and Tabldy, this plant has gained an interest for study because have many therapeutic benefits and low side effects and have high demand in the world market and is expected tobe replace chemical products. Plant pulp extracts contain chemical constituents such as polyphenol, which are responsible for Antimicrobial activity and cytotoxic activity. The current studied investigates of the edible parts of Adansonia digitata ethanoic pulp extract against bacteria, fungi and anticancer. Methodology:- HPLC used to identify the polyphenol compound, agar well diffusion method used to estimate the antimicrobial activity and to estimate anticancer of pulp edible parts of Adansonia digitataused MTT protocol. Results:- Polyphenol constituents of Adansonia digitata pulp extracts was examined by HPLC contained 18 compounds have antimicrobial activity to pathogenic bacteria (Bacillus subtilis (ATCC 6633), Escherichia coli (ATCC 8739), Salmonella typhi (ATCC 6539), fungi Candida albicans(ATCC 10221), Aspergillus niger ATCC 16888) compare with antibiotic for bacteria (Gentamicin) and for fungi (Fluconazole), also have high cytotoxicity against six cancer cell line such as Hela (The line is derived from cervical cancer), Hep G2 (a human liver cancer), A549 (lung cancer), A-431 (cells epidermis carcinoma), PC3 (a human prostate cancer) and T-47D (human breast cancer cell line).