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August 21, 2025Journal of Surgical OncologyOpen Access

Factors Associated With Residual Positive Lymph Nodes With Targeted Axillary Lymph Node Dissection for Breast Cancer and Accuracy of Clipped Node Retrieval in Non‐Mapping Patients

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Authors

DBDanielle BrabenderAGAlexa GriffithsKLKaye A. Lu

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Overview

Retrospective analysis reveals axillary lymph node dissection's impact on lymph node status in breast cancer, suggesting alternatives to surgery.

Key Points

  • Approximately 60% of patients with pN+ converted to ypN0 after neoadjuvant chemotherapy, indicating effective treatment response.
  • Of 198 patients, 58% with ypN+ status had additional positive non-sentinel lymph nodes in the axillary lymph node dissection specimen.
  • The study highlights that axillary lymph node dissection might not be required for many patients post-neoadjuvant chemotherapy, reducing surgical burden.
  • Correlations were found between the node status at surgery and response to neoadjuvant chemotherapy, supporting a reevaluation of surgical approaches.

Cite This Study

Brabender et al. (2025) studied this question.

synapsesocial.com/papers/68af5210ad7bf08b1ead97bbhttps://doi.org/10.1002/jso.70070
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Impact of Neoadjuvant Chemotherapy on Axillary Surgical Management of Patients With Breast Cancer and Positive Axillary Lymph Nodes2024 · 3 citations
  2. 2Factors Associated with Omission of Axillary Lymph Node Dissection for Patients with Clinical Node-Positive Breast Cancer Who have Residual Nodal Disease on Pathology After Neoadjuvant Chemotherapy2026 · 1 citations
  3. 3The Role of Axillary Lymph Node Dissection in Breast Cancer Patients With Residual Nodal Disease After Receiving Neoadjuvant Chemotherapy2025
  4. 4Clipping the Positive Lymph Node in Patients with Clinically Node Positive Breast Cancer Treated with Neoadjuvant Chemotherapy: Impact on Axillary Surgery in the ISPY-2 Clinical Trial2024 · 4 citations
  5. 5Targeted axillary dissection reduces residual nodal disease in clinically node- positive breast cancer after neoadjuvant chemotherapy2024 · 7 citations