Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

Shichang Li; Zongyi Yu; Liyuan Duan; Cunfei Ma; Jingnan Zhao; Huinan Sun; Guofeng Zhao; Ping Yi; Qilei Liu; Qingwei Meng

doi:10.1039/d5cc02725j

January 1, 2025Chemical Communications

Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

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Key Points

Oxidative cleavage of cyclohexanones to mono-carboxylic acids was successfully achieved under mild conditions, using an iron/anthraquinone system.
The process operates effectively under visible-light conditions at 0 °C, highlighting its potential for energy-efficient chemical transformations.
This approach leverages a dual catalytic system, representing an innovative method for C–C bond cleavage in organic synthesis.
The findings could lead to advancements in synthetic organic chemistry, promoting milder reaction conditions for valuable chemical transformations.

Implication

Dual catalytic system enables mild oxidative cleavage of cyclohexanones to acids, suggesting novel applications in synthesis.

Abstract

This study introduces an Fe/anthraquinone dual catalytic system for oxidative cleavage of non-strained cyclohexanones to mono-carboxylic acids under mild visible-light conditions (0 °C).

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af521fad7bf08b1ead9f12 https://doi.org/10.1039/d5cc02725j

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Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

Key Points

Implication

Abstract

Discussion

Cite This Study

Iron–anthraquinone cooperative catalysis enables mild C–C bond cleavage of cyclohexanones via oxygen-centered radicals

Key Points

Implication

Abstract

Discussion

Cite This Study

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