Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 13, 2026Angewandte Chemie

Atomically Dispersed Iron‐Catalyzed Aerobic Hydroxylation of Allylic and Propargylic C─H Bonds

View Full Paper
Ask AI
Bookmark
Share

Authors

YJYijie JiangMinistry of EducationFQFuhua QinMinistry of EducationXWXu WangHorological Research Institute of Light Industry

Discussion

Loading...

Member takes

Implication

Randomized trial demonstrates efficient C─H bond hydroxylation using iron catalysts, highlighting a sustainable approach.

Key Points

  • This research aims to explore the potential of atomically dispersed iron catalysts for selective hydroxylation of C─H bonds using molecular oxygen.
  • Developed a heterogeneous catalyst with atomically dispersed iron in a nitrogen-doped carbon matrix.
  • Conducted mechanistic studies to identify the catalytic activity of FeN x sites.
  • Tested the catalyst for hydroxylation of various allylic and propargylic substrates at 30°C using air.
  • Achieved selective hydroxylation of allylic and propargylic C─H bonds with a broad range of substrates.
  • Demonstrated excellent functional-group tolerance and late-stage oxidation of complex molecules.
  • Showed that catalytic activity is due to highly dispersed FeN x sites, enhancing site and chemoselectivity.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf5d7faef96ed7f057cc3https://doi.org/10.1002/ange.2913960
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chemoselective 1,2-Sulfonamidoazidation of Styrene via Single-Atom-Site Cobalt Catalysis2026 · 15 citations
  2. 2Phenylenediamine-Based FeN<sub><i>x</i></sub>/C Catalyst with High Activity for Oxygen Reduction in Acid Medium and Its Active-Site Probing2014 · 632 citations
  3. 3Palladium‐Catalyzed Oxidation Reactions of Alkenes with Green Oxidants2019 · 73 citations
  4. 4<i>syn</i>-1,2-Amino Alcohols via Diastereoselective Allylic C−H Amination2007 · 340 citations
  5. 5Iron-catalyzed arene C−H hydroxylation2021 · 129 citations