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August 21, 2025Frontiers in ImmunologyOpen Access

Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypes

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Immune cell interactions revealed distinct dedifferentiation states linked to tumor invasiveness.
Cancer-associated fibroblasts emerged as the most abundant cell type, influencing tumor microenvironment dynamics.
The spatial transcriptomics approach analyzed tumor samples, uncovering unique gene expression profiles in subtypes.
Findings suggest critical pathways in tumor progression that could inform future cancer therapies.

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Analysis shows dedifferentiation patterns and immune cell interactions in lung adenocarcinoma subtypes, indicating potential therapeutic targets.

Deng et al. (2025) studied this question.

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Analysis shows dedifferentiation patterns and immune cell interactions in lung adenocarcinoma subtypes, indicating potential therapeutic targets.