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August 20, 2025Zanco Journal of Medical SciencesOpen Access

Role of Echinococcus granulosus Mitochondrion Partial Gene Polymorphism in Responsiveness to Albendazole Treatment in Experimentally Infected Mice

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Authors

HAH. M. A. Al-Sakee

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Overview

Experimental analysis reveals that mitochondrial polymorphisms influence albendazole responsiveness in Echinococcus granulosus, suggesting targeted treatment potential.

Key Points

  • Polymorphic sequence profiles in the Echinococcus granulosus mitochondrion are linked to albendazole treatment effectiveness.
  • Among 14 hydatid cyst isolates, 5 showed significant DNA sequence polymorphisms affecting treatment response.
  • In vivo experiments utilized protoscoleces from infected sheep livers to assess drug efficacy in mice.
  • Findings may guide future studies on treating cystic echinococcosis across different intermediate hosts.

Cite This Study

H. M. A. Al-Sakee (2025) studied this question.

synapsesocial.com/papers/68af5228ad7bf08b1eada14dhttps://doi.org/10.15218/zjms.2025.036
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