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August 22, 2025Phosphorus, sulfur, and silicon and the related elements

Synthesis, antioxidant activity, molecular docking, drug likeness and DFT studies of 1,2,4-triazole Schiff bases clubbed with heterocyclic moieties using Amberlite IR-4B as a catalyst

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Authors

SASomaia M. Abdel‐KariemTATarik E. AliABAbeer Abdelaziz Bukhari

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Overview

Synthesis of triazole Schiff bases shows significant antioxidant activity and molecular docking with ascorbic acid, indicating potential therapeutic applications.

Key Points

  • Compound 2b demonstrated strong antioxidant activity, outperforming standard antioxidant measures.
  • Molecular docking studies indicate that synthesized compounds interact similarly to ascorbic acid.
  • Using Amberlite IR-4B as a catalyst, a range of triazole Schiff bases were efficiently synthesized.
  • Theoretical calculations via DFT provided insights into the stability and efficiency of the compounds.

Cite This Study

Abdel‐Kariem et al. (2025) studied this question.

synapsesocial.com/papers/68af53ffad7bf08b1eadab75https://doi.org/10.1080/10426507.2025.2548582
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