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August 15, 2025International Journal of Molecular SciencesOpen Access

Salivary Protein Profile in Patients with Recurrent Aphthous Stomatitis: A Pilot Proteomic Study

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Authors

FFFrancesco FrancoPoliclinico Tor VergataNNNima NamarvariAGAlessio GambinoDepartment of Medical Sciences

Discussion

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Implication

Pilot proteomic study identifies altered salivary proteins in recurrent aphthous stomatitis, suggesting a role for CST1.

Key Points

  • Cystatin SN was significantly downregulated in patients with recurrent aphthous stomatitis (RAS).
  • 17 differentially expressed proteins were identified between healthy subjects and RAS patients during ulcers.
  • Mass spectrometry and 2D-electrophoresis techniques were used to analyze salivary proteins.
  • Results hint at a potential link between Cystatin SN levels and the inflammatory process of RAS.

Cite This Study

Franco et al. (2025) studied this question.

synapsesocial.com/papers/68af5407ad7bf08b1eadad78https://doi.org/10.3390/ijms26167878
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Also Consider

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  4. 4Complement activation product C4d in oral and oropharyngeal squamous cell carcinoma2015 · 44 citations
  5. 5Cystatin SN (CST1) as a Novel Salivary Biomarker of Periodontitis2023 · 7 citations