Intrauterine device (IUD) insertion and endometrial biopsy are two common and essential procedures routinely performed in office-based gynecology. IUDs offer highly effective contraception and also serve as important treatments for dysmenorrhea, abnormal uterine bleeding, and endometrial hyperplasia or cancer. Endometrial biopsy remains a first-line diagnostic tool for evaluating abnormal uterine bleeding. Despite their utility, both procedures are often associated with moderate to severe pain, which can discourage patients from pursuing them. As patient comfort becomes an increasing priority for both patients and providers, clinicians should become familiar with the effective analgesic strategies available in this setting.
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Gryn et al. (2025) studied this question.
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