What type of study is this?

This is a Animal Study study (also classified as: In Vitro Study).

August 22, 2025Nature CommunicationsOpen Access

Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells

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Authors

GTGauthier ToulouseUniversité Claude Bernard Lyon 1 WJWilliam JarassierUniversité Claude Bernard Lyon 1 SJSabrina JagotUniversité Claude Bernard Lyon 1

Discussion

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Implication

Combined analysis shows early lineage segregation of primary and secondary myotubes in avian embryos, highlighting roles of TCF-LEF/β-catenin signaling and satellite cells.

Key Points

Primary myotubes and secondary myotubes arise from distinct progenitor populations during muscle development.
In this study, reporter-positive cells were found to exclusively give rise to primary myotubes, while reporter-negative cells produce secondary myotubes and satellite cells.
Analysis included in vivo electroporation and TCF-LEF/β-catenin signaling to trace limb muscle progenitors over developmental stages.
These findings help clarify muscle fiber diversity origins and lineage contributions to skeletal muscle function.

Cite This Study

Toulouse et al. (2025) studied this question.

synapsesocial.com/papers/68af540fad7bf08b1eadb08a https://doi.org/10.1038/s41467-025-61767-1

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Implication

Combined analysis shows early lineage segregation of primary and secondary myotubes in avian embryos, highlighting roles of TCF-LEF/β-catenin signaling and satellite cells.

Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells

Discussion

Member takes

Implication

Key Points

Cite This Study

Early lineage segregation of primary myotubes from secondary myotubes and adult muscle stem cells

Discussion

Member takes

Implication

Key Points

Cite This Study

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