Expression of NY-ESO1 Protein in Multiple Myeloma

Objective: To evaluate the proportion of New York esophageal squamous cell carcinoma 1 (NY-ESO1) protein expression, via immunohistochemistry staining in bone marrow of multiple myeloma patients. Additionally, to correlate the expression with clinical data and survival outcomes.Material and Methods: The study population were multiple myeloma patients, diagnosed by bone marrow biopsy in Songklanagarind hospital; from 2012 and 2015. The clinical data and survival outcomes were collected. All cases were stained with NY-ESO1 (E978) antibody and interpreted by one pathologist and a resident. Results: There were 61 patients that reached the criteria for this study. NY-ESO1 expression was detected in 4 of 61 cases (6.6%). The expression of NY-ESO1 was associated with serum albumin levels (p-value<0.01). However, no association between NY-ESO1 expression nor survival outcome was identified by survival analysis. Conclusion: NY-ESO1 immunostaining showed low percentages of expression in multiple myeloma neoplastic cells, and was not associated with survival outcome.