Clinical and Immunological Study of The Cytokine Profile of Auxiliary T-Lymphocytes in Children Up To 3 Years of Age with Congenital Cleft Lip and Palate in Community Aquired Pneumonia

OBJECTIVE: To evaluate the synthesis of major cytokines characteristic of Th1/Th2/Th17 immune responses in children with congenital cleft lip and palate in acute CAPeumonia. MATERIAL AND METHODS: The present study included 46 children with an established diagnosis of community acquired pneumonia (22 children with CCLP and 24 children without CCLP formed the comparison group) and 20 practically healthy children formed the control group. The concentration of interleukins and interferon-γ in the blood serum was determined by the method of solid-phase enzyme-linked immunosorbent assay (ELISA) using the test systems of Vector-Best JSC (Novosibirsk, Russia). RESULTS: It was found that in groups of children with CAP, both with congenital cleft lip and without congenital pathology, there was a significant increase in the content of IL-17A, IL-4 in the peripheral blood and a deficiency of IFN-γ in young children, which indicates an imbalance in the immune response that can affect the course and severity of the infection.