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August 21, 2025European Journal of HistochemistryOpen Access

P48 | New Strategies to Improve the Response of Aml Cells to Targeted Therapies by Overcoming the Protective Effect of the Bone Marrow Mesenchymal Stem Cells

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Overview

Observational study reveals drug resistance in acute myeloid leukemia cells due to protective bone marrow mesenchymal stem cells, suggesting new treatment strategies.

Key Points

  • The combination of RBA and the Bcl-2 inhibitor Venetoclax significantly prolongs lifespan in a murine model of acute myeloid leukemia.
  • Proteomic analysis shows the involvement of extracellular matrix reorganization in the protective crosstalk between mesenchymal stem cells and AML.
  • This research analyzed the morphology of bone marrow mesenchymal stem cells after exposure to therapeutic combinations using live-cell imaging.
  • Targeted therapies for AML could improve by overcoming the protective effects of the bone marrow microenvironment.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68af55c6ad7bf08b1eadbb25https://doi.org/10.4081/ejh.2025.4370
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increase in serum IL-4 in response to venetoclax therapy in xenograft models of acute myeloid leukaemia2024
  2. 2Inhibition of <scp>CDK</scp>9 enhances <scp>AML</scp> cell death induced by combined venetoclax and azacitidine2025 · 1 citations
  3. 3Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection2023 · 9 citations
  4. 4Mass spectrometry-based molecular investigation of dual AXL and BCL-2 inhibition in acute myeloid leukemia2026
  5. 5EFFICACY OF VENETOCLAX AND AZACITIDINE FOR TARGETING LEUKEMIC STEM CELL IN ACUTE MYELOID LEUKEMIA2024 · 10 citations