Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 18, 2025Current Enzyme Inhibition

Exploring α-Glucosidase Inhibitory, Antioxidant, and Antimicrobial Properties of Tinospora sinensis (Lour.) Merr.

View Full Paper
Ask AI
Bookmark
Share

Authors

AAAchyut AdhikariUniversity of Hawaiʻi at MānoaBABinita AdhikariJohns Hopkins UniversityDKDeepa KarkiTribhuvan University

Discussion

Loading...

Member takes

Implication

Exploratory analysis shows Tinospora sinensis can inhibit α-glucosidase and demonstrates significant antioxidant and antimicrobial activities.

Key Points

  • The extract of Tinospora sinensis exhibited substantial α-glucosidase inhibition with an IC50 of 36.40 µg/mL, influencing diabetes management significantly.
  • Measured total phenolic content (TPC) was 181.41 mg GAE/g, while the antioxidant activity determined via DPPH showed an IC50 of 111.43 µg/mL.
  • Phytochemical analysis identified alkaloids and flavonoids among other compounds, supporting the medicinal use of T. sinensis.
  • Antimicrobial evaluation revealed activity against Staphylococcus aureus with a 9 mm zone of inhibition, indicating potential therapeutic applications.

Cite This Study

Adhikari et al. (2025) studied this question.

synapsesocial.com/papers/68af55c6ad7bf08b1eadbb77https://doi.org/10.2174/0115734080391554250807044513
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of the Active Compounds and Significant Pathways of Artemisia Annua in the Treatment of Non-Small Cell Lung Carcinoma based on Network Pharmacology2020 · 19 citations
  2. 2Ethnomedicinal uses of plants among the Newar community of Pharping village of Kathmandu District, Nepal1970 · 110 citations
  3. 3Antioxidant, Antidiabetic and Antimicrobial Properties of Tinospora cordifolia (Thumb) Miers from Different Geo-Ecological Regions of India2024 · 1 citations
  4. 4Quantification of the Antioxidant Activity of Plant Extracts: Analysis of Sensitivity and Hierarchization Based on the Method Used2020 · 521 citations
  5. 5Antidiabetic claims of Tinospora cordifolia (Willd.) Miers: critical appraisal and role in therapy2015 · 117 citations