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Long-Term Durability and Variant-Specific Modulation of SARS-CoV-2 Humoral and Cellular Immunity over Two Years

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Longitudinal analysis explores immune memory and variant-specific immune modulation, suggesting implications for public health strategies.

Anti-spike IgG levels remained stable and increased after immune stimulation, indicating robust immune memory.
Neutralizing capacity correlated with IgG levels, showing strong long-term stability for pre-Omicron variants, but less so for Omicron.
Assessment included intracellular cytokine staining (ICS) and activation-induced marker (AIM) assays to evaluate T cell responses over time.
Insights into long-term protection against SARS-CoV-2 variants highlight the need for evolving public health strategies.

Matei et al. (2025) studied this question.

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Longitudinal analysis explores immune memory and variant-specific immune modulation, suggesting implications for public health strategies.