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August 21, 2025International Journal of Molecular SciencesOpen Access

Antimicrobial Peptides of the Cathelicidin Family: Focus on LL-37 and Its Modifications

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Authors

OVOlga Evgenevna VoronkoKoltzov Institute of Developmental BiologyVKVictoria A. KhotinaShiraz University of Medical SciencesDKDmitry KashirskikhKoltzov Institute of Developmental Biology

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Implication

This review showcases strategies to improve ll-37's therapeutic potential in antimicrobial peptides, highlighting modifications and delivery systems.

Key Points

  • Enhanced biological activity is achieved through modifications of ll-37, leading to improved therapeutic potential.
  • LL-37-based analogs show promise in antimicrobial applications, with reduced toxicity and increased proteolytic resistance.
  • Nanoscale delivery systems facilitate targeted delivery and prolong half-life, tackling challenges in clinical applications.
  • Advances in computational modeling and high-throughput screening are important for optimizing cathelicidin modifications.

Cite This Study

Voronko et al. (2025) studied this question.

synapsesocial.com/papers/68af55c6ad7bf08b1eadbc55https://doi.org/10.3390/ijms26168103
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