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August 22, 2025AllergyOpen Access

Natural History of Airway Hyperresponsiveness and Its Association With Asthma Traits

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Observational study found decreased airway hyperresponsiveness prevalence in adolescents with asthma, suggesting age factors in asthma diagnosis.

Airway hyperresponsiveness prevalence showed a marked decrease from 21.6% at 10 years to 5% at 18 years.
In participants tested at both ages, 80.9% of those with airway hyperresponsiveness at 10 years no longer exhibited it at 18 years.
Analysis involved methacholine bronchial challenge tests across a population cohort at ages 10, 18, and 26 years.
Understanding the natural history of airway hyperresponsiveness highlights the need for age considerations in asthma characteristics.

Carra et al. (2025) studied this question.

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Observational study found decreased airway hyperresponsiveness prevalence in adolescents with asthma, suggesting age factors in asthma diagnosis.