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This is a Case Report study (also classified as: Literature Review).

August 22, 2025Open Access

Thrombotic thrombocytopenic purpura as a complication of pembrolizumab: a case report and literature review

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Case report highlights TTP as an adverse event of pembrolizumab in a 76-year-old with renal cancer, suggesting increased awareness is needed.

TTP occurred in a 76-year-old man after his initial pembrolizumab injection, leading to severe complications.
The patient's ADAMTS13 activity was found to be critically low at 3.8%, confirming the diagnosis of TTP.
Given the patient's poor condition, no plasma exchange was initiated, resulting in his passing 15 days after treatment.
Raising awareness of TTP as a rare but critical complication of pembrolizumab can aid in timely diagnosis and management.

Palega et al. (2025) studied this question.

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Case report highlights TTP as an adverse event of pembrolizumab in a 76-year-old with renal cancer, suggesting increased awareness is needed.