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This is a In Vitro Study study.

Storage damage of cold-stored whole blood in CPDA maintenance fluid during the whole effective storage period

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Observational analysis tracked changes in whole blood components over 35 days, suggesting optimal use within 14 days for trauma care.

CS-WB maintained optimal oxygen carrying capacity and coagulation function up to 14 days, crucial for trauma management.
On day 21, significant decreases in RBC ATP levels and platelet function were noted, indicating storage damage progression.
Stored whole blood was assessed using indicators of red blood cells, plasma components, and platelets across a timeframe of 35 days.
Findings highlight the importance of timely use of cold-stored whole blood to preserve hemostatic properties in emergency situations.

He et al. (2025) studied this question.

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