This analysis demonstrates how petri nets reveal dynamics and attractors in multilevel models of gene-regulatory networks, suggesting new frameworks.
We discuss connections between different types of models of gene-regulatory network dynamics that include Boolean, finite multilevel and monotone Boolean models. We recast the methodology of describing attractors of Boolean and finite multilevel dynamics using motifs of the expanded network e R N in terms of Petri net dynamics on e R N . We show that the Petri net can be used to recover dynamics of the finite multilevel dynamics on the state transition graph. We conclude with new insights that the expanded network viewpoint offers for the robustness of equilibria and complex attractors.
No takes yet. Share an insight, caveat, or question.
Andreas et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: