Effectiveness and safety of upadacitinib in juvenile idiopathic arthritis: beyond the polyarticular subset in pediatric and adult patients

Journal Article Accepted manuscript Effectiveness and safety of upadacitinib in juvenile idiopathic arthritis: beyond the polyarticular subset in pediatric and adult patients Get access Stefania Costi , Stefania Costi Department of Rheumatology and Medical Sciences, Unit of Pediatric Rheumatology, ASST G. Pini-CTO, Milan, Italy Corresponding author: Dr Stefania Costi, Unit of Pediatric Rheumatology, ASST G. Pini—CTO, Via Gaetano Pini 9, Milan, 20122, Italy. [email protected] https://orcid.org/0000-0002-4468-6839 Search for other works by this author on: Oxford Academic PubMed Google Scholar Luca Ingrao , Luca Ingrao Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milan, Italy https://orcid.org/0009-0003-2046-9316 Search for other works by this author on: Oxford Academic PubMed Google Scholar M Giovanna Lommano , M Giovanna Lommano Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, 'Carlo Urbani' Hospital, Jesi, Ancona, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Gilberto Cincinelli , Gilberto Cincinelli Department of Rheumatology and Medical Sciences, Unit of Clinical Rheumatology, ASST G. Pini-CTO, Milan, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Francesco Baldo , Francesco Baldo Department of Rheumatology and Medical Sciences, Unit of Pediatric Rheumatology, ASST G. Pini-CTO, Milan, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Achille Marino , Achille Marino Department of Rheumatology and Medical Sciences, Unit of Pediatric Rheumatology, ASST G. Pini-CTO, Milan, Italy https://orcid.org/0000-0002-3027-8009 Search for other works by this author on: Oxford Academic PubMed Google Scholar Roberto Caporali , Roberto Caporali Department of Rheumatology and Medical Sciences, Unit of Pediatric Rheumatology, ASST G. Pini-CTO, Milan, ItalyDipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milan, ItalyDepartment of Rheumatology and Medical Sciences, Unit of Clinical Rheumatology, ASST G. Pini-CTO, Milan, Italy https://orcid.org/0000-0001-9300-6169 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cecilia Beatrice Chighizola Cecilia Beatrice Chighizola Department of Rheumatology and Medical Sciences, Unit of Pediatric Rheumatology, ASST G. Pini-CTO, Milan, ItalyDipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza 2023-2027, University of Milan, Italy https://orcid.org/0000-0002-3787-9632 Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, keaf442, https://doi.org/10.1093/rheumatology/keaf442 Published: 19 August 2025 Article history Received: 09 May 2025 Revision received: 18 July 2025 Accepted: 21 July 2025 Published: 19 August 2025