Abstract Placenta-related complications such as pre-eclampsia, small-for-gestational-age (SGA) and stillbirth contribute significantly to maternal and perinatal mortality globally, with the highest burden in low– and middle-income countries (LMICs). The potential impact of inadequate access to household water, sanitation, and hygiene (WASH) on these outcomes has not been quantified. This study investigates the association between household WASH conditions and pre-eclampsia, stillbirth and SGA in The Gambia, Kenya, and Mozambique, where access to safe WASH services remains a challenge. This study is nested within the PRECISE (PREgnancy Care Integrating Translational Science, Everywhere) study, a prospective observational cohort including 5,745 unselected pregnant women. Multivariate logistic regression analysis was used to test the associations between household WASH and pre-eclampsia, SGA or stillbirth. Compared to women with piped water in their homes, those relying on other improved water sources had higher odds of experiencing selected placenta-related complications (adjusted odds ratio (aOR) 1.36 95% confidence interval (CI) 1.18, 1.57, p < 0.001). Country-specific analyses revealed differences across settings. In both The Gambia (1.52 1.03, 2.24, p = 0.034) and Kenya (1.29 1.04, 1.59, p = 0.019), the use of other improved water sources was associated with increased odds of selected placenta-related complications. Unimproved sanitation, compared with improved sanitation, was associated with increased odds of selected placenta-related complications in Mozambique (1.35 1.02, 1.80, p = 0.038). The findings highlight the role of household-level WASH conditions as potential risk factors for placenta-related complications. Even when water sources are improved, contamination can occur during collection, transport and storage, while unimproved sanitation can increase pathogen exposure. These results underline the need for targeted WASH interventions to reduce pregnancy-related risks. Addressing these gaps could significantly reduce the prevalence of placenta-related complications, contributing to improved maternal and neonatal health outcomes in LMICs. Future research should explore the mechanisms linking WASH to pre-eclampsia, SGA and stillbirth and other placenta-related complications, and assess the effect of comprehensive WASH interventions.
Wells et al. (Sat,) studied this question.