Assessment finds no cross-reactivity of antibodies against H5N1 in retail workers despite strong seasonal influenza immunity, suggesting vaccine improvements.
This study evaluated whether immunity from seasonal influenza induces cross-reactive antibodies against recent avian and bovine H5N1 strains in serum from retail workers. Despite strong neutralizing activity against seasonal strains, no cross-reactivity against H5N1 was detected, emphasizing the need to assess broader immune responses and targeted vaccines for H5N1 viruses.
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Arroyave et al. (2025) studied this question.
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