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August 20, 2025Open Access

Structure-activity relationship of Cu(II) and Pd(II) thiosemicarbazone complexes with anticancer and antibacterial properties

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Authors

BRBartłomiej RogalewiczLodz University of TechnologyMIMagdalena IwanMedical University of LublinMŚMarcin Świa̧tkowskiLodz University of Technology

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Overview

Synthesis reveals Cu(II) and Pd(II) complexes show cytotoxic effects in melanoma, indicating potential for antibacterial applications.

Key Points

  • Cu(II) and Pd(II) thiosemicarbazone complexes demonstrated significant anticancer activity, particularly against melanoma cells, with notable cytotoxicity.
  • Lead complexes, Pd(dm-TSC-pCl)2 and Cu(b-TSC)2, exhibited apoptosis through cell cycle arrest and DNA damage, providing insight into their mechanisms.
  • Structure-activity relationship analysis showed that chlorine substituents generally reduced anticancer activity, indicating careful ligand design is vital.
  • Antimicrobial testing revealed strain-specific efficacy, with MIC values against E. coli as low as 3.125 mg/L, highlighting the therapeutic potential of these complexes.

Cite This Study

Rogalewicz et al. (2025) studied this question.

synapsesocial.com/papers/68af55dead7bf08b1eadccb3https://doi.org/10.26434/chemrxiv-2025-p1fdc
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