Dose-response modeling shows gene and protein changes in human white blood cells, suggesting improved risk assessment for low-dose radiation.
Background The current radiation protection framework extrapolates health risks from high-dose exposures based on a linear, no-threshold model. However, empirical data on molecular effects below 0.1 Gy are lacking, creating uncertainties in risk assessments. To address this, we used benchmark dose (BMD) modeling, commonly applied in chemical hazard assessment, to analyze gene and protein expression changes in human white blood cells, providing insights into dose-response relationships following low-dose radiation (LDR) exposure.
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Khilji et al. (2025) studied this question.
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