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August 15, 2025PeerJOpen Access

NLRP3 inflammasome and pyroptosis: implications in inflammation and multisystem disorders

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Authors

XLXiaodi LiZZZhiyuan ZhangYHYang Han

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Overview

Review demonstrates NLRP3 inflammasome and pyroptosis roles in inflammation, suggesting new therapeutic targets for diseases.

Key Points

  • Pyroptosis is a key mechanism in immune responses and inflammation, driven by the NLRP3 inflammasome's activation.
  • NLRP3 inhibitors like MCC950 show protective effects against NLRP3-mediated inflammatory diseases and related disorders.
  • This review assesses the structure and mechanisms of the NLRP3 inflammasome, revealing its significant role in disease pathogenesis.
  • Targeting gasdermin D as a therapeutic tool may enhance strategies for managing various inflammatory conditions.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af56f4ad7bf08b1eadce6dhttps://doi.org/10.7717/peerj.19887
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diverse functions of NLRP3 inflammasome in PANoptosis and diseases2025 · 20 citations
  2. 2Mechanism of NLRP3 inflammasome activation2014 · 752 citations
  3. 3NLRP3 and beyond: inflammasomes as central cellular hub and emerging therapeutic target in inflammation and disease2025 · 50 citations
  4. 4The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities2026 · 27 citations
  5. 5The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death2026