Exhaustive Hydrodechlorination of Trichloroacetamides under Electrochemical Conditions at Ambient Temperature

A simple yet efficient electrochemical method is developed for accessing acetamide derivatives from allylic trichloroacetamides derived from the Overman reaction, even though the transformation is synthetically challenging under reductive conditions. The proposed mechanistic pathway of the reaction is fully supported by control experiments and electrochemical studies. Other attractive features, such as inexpensive electrode material and electrolytes, minimal chemical waste, broad substrate scope, consistent yield, operational simplicity, and scalability, make this method appealing.