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August 15, 2025Open Access

Supplementary Fig. S27 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer

Xianfeng Xu Caiwang Yan Lijun Bian Zhe Li Yuhui Yu Xia Zhu Yun Gao Hao Xu Fengyuan Li Yao Liu Ping Sun Zheng Wang Yao Fu Yue Jiang Juncheng Dai Hongxia Ma Zhibin Hu Hongbing Shen Gang Li Cheng Wang Guangfu Jin

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Key Points

Kaplan-Meier curves show significant differences in overall survival between SMAD4 wild-type and mutated tumors in gastric cancer.
Overall survival rates differ, with SMAD4 wild-type patients experiencing more favorable outcomes in intestinal metaplasia.
Genomic analyses reveal evolving characteristics of intestinal metaplasia and gastric cancer through tumor mutations.
Findings support the potential for targeted therapies based on the SMAD4 mutation status in gastric cancer.

Implication

Observational analysis shows differences in overall survival for SMAD4 wild-type and mutated gastric tumors, indicating genomic influence.

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd174 https://doi.org/10.1158/0008-5472.29919153

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Fig. S11 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025
2Supplementary Fig. S13 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025
3Supplementary Fig. S4 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025
4Supplementary Fig. S10 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025
5Supplementary Fig. S12 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025

Supplementary Fig. S2 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025
Supplementary Fig. S17 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025
Supplementary Fig. S3 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025