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August 15, 2025Open Access

Supplementary Fig. S5 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer

Xianfeng Xu Caiwang Yan Lijun Bian Zhe Li Yuhui Yu Xia Zhu Yun Gao Hao Xu Fengyuan Li Yao Liu Ping Sun Zheng Wang Yao Fu Yue Jiang Juncheng Dai Hongxia Ma Zhibin Hu Hongbing Shen Gang Li Cheng Wang Guangfu Jin

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Key Points

Higher mutation burden is observed in individuals with gastric cancer, especially those with alcohol and tobacco exposure.
Mutation burden comparison between alcohol drinkers and non-drinkers indicates potential risk factors, noting specific genetic alterations.
Analysis focused on mutation burden related to environmental factors like smoking and H. pylori infection statuses.
These findings suggest lifestyle factors may contribute to the risk of developing gastric cancer and intestinal metaplasia.

Implication

Comparison of mutation burden reveals smoking, alcohol, and H. pylori effects in gastric cancer risk.

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Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1b5 https://doi.org/10.1158/0008-5472.29919138

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1Supplementary Fig. S13 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025
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Supplementary Fig. S14 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer2025