Analysis reveals improved anticancer activity of flavin-functionalised Pt(IV) prodrugs in cell models, suggesting potential for photoactivated treatment.
Synchrotron-based X-ray spectromicroscopy reveals enhanced cellular uptake and remarkably fast, efficient photoactivation of Pt(IV) prodrugs bearing flavin groups. These features correlate with superior anticancer activity compared to non-conjugated analogues, highlighting the potential of flavin-functionalised Pt(IV) complexes as candidates for photoactivated chemotherapy (PACT).
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Zingales et al. (2025) studied this question.
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