Flavoplatins: Photoactivated platinum(IV) prodrugs bearing axial N-donors that trigger pyroptosis and reduce drug resistance

Qiyuan Zhou; Nang-Hei Chu; Jiaqian Xu; Kwok-Chung Law; Guangyu Zhu

doi:10.1039/d6qi00078a

January 1, 2026Inorganic Chemistry FrontiersOpen Access

Flavoplatins: Photoactivated platinum(IV) prodrugs bearing axial N-donors that trigger pyroptosis and reduce drug resistance

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Key Points

This research aims to explore the effectiveness of N-donor ligands in photoactivated platinum(IV) prodrugs for triggering cell death.
Synthesize platinum(IV) prodrugs with axial N-donors.
Evaluate the photoactivation process and its impact on cancer cells.
Assess the induction of pyroptosis and resistance mechanisms.
N-donor platinum(IV) prodrugs successfully induce pyroptosis in targeted cells.
The photoactivation enhances anticancer activity compared to traditional Pt(II) drugs.
Reduced drug resistance observed in treated cancer cells.

Implication

Photoactivated platinum(IV) prodrugs induce pyroptosis in cancer cells, suggesting a new approach to overcome drug resistance.

Abstract

Photoactivated Pt(IV) anticancer prodrugs derived from clinical Pt(II) drugs have garnered significant attention in recent years, with O-donor ligands being the most commonly used photosensitive axial ligands. N-donor ligands, however,...

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/699a9d8e482488d673cd3741 https://doi.org/10.1039/d6qi00078a

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Flavoplatins: Photoactivated platinum(IV) prodrugs bearing axial N-donors that trigger pyroptosis and reduce drug resistance

Key Points

Implication

Abstract

Discussion

Cite This Study

Flavoplatins: Photoactivated platinum(IV) prodrugs bearing axial N-donors that trigger pyroptosis and reduce drug resistance

Key Points

Implication

Abstract

Discussion

Cite This Study

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