What type of study is this?

This is a Observational study (also classified as: In Vitro Study).

August 22, 2025Cancer Biology & TherapyOpen Access

MiR-135a-3p inhibits the progression of prostate cancer by targeting TLR4

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Observational analysis reveals low mir-135a-3p levels correlate with poor prognosis in prostate cancer patients, highlighting TLR4's role.

Low mir-135a-3p expression predicts poor patient prognosis in prostate cancer, emphasizing the importance of this microRNA.
The study observed that 125 cancer tissue specimens showed significant correlations with TNM stage and Gleason score.
Analysis included a dual-luciferase reporter assay to confirm the interaction between mir-135a-3p and TLR4, crucial for understanding tumor development.
This research underscores the potential of mir-135a-3p as a therapeutic target for improving prostate cancer outcomes.

Li et al. (2025) studied this question.

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Observational analysis reveals low mir-135a-3p levels correlate with poor prognosis in prostate cancer patients, highlighting TLR4's role.