January 1, 2025Chemical CommunicationsOpen Access

Combatting Resistance: Natural Products as Tools to Drive the Discovery of Untapped Antibiotic Targets

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New antibiotics can be developed from natural products, combatting drug resistance effectively.
Natural product total synthesis enhances antibiotic discovery, focusing on unique mechanisms of action through innovative techniques.
Research emphasizes the potential of untapped antibiotic targets from natural sources, aiming to advance treatment options against resistant pathogens.
The findings suggest significant promise in leveraging natural products, aiming for diverse antibiotic strategies to address ongoing resistance issues.

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This article reveals how natural product synthesis drives new antibiotic discovery, highlighting unique mechanisms and targets to combat resistance.

This featured article highlights the importance of natural product total synthesis for developing new antibiotics with unique mechanisms of action.

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Hedges et al. (2025) studied this question.

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This article reveals how natural product synthesis drives new antibiotic discovery, highlighting unique mechanisms and targets to combat resistance.

This featured article highlights the importance of natural product total synthesis for developing new antibiotics with unique mechanisms of action.