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August 21, 2025Advanced Healthcare Materials

Bioinspired Inhalable Nanoparticles Combining Chinese Herbal Tetrandrine with Pirfenidone Overcome Idiopathic Pulmonary Fibrosis via Coordinated Collagen Modulation and Fibroblast Autophagy Regulation

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Authors

XZXinrui ZhangXDXiangfeng DuanXXXiuzhi Xie

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Overview

Bioinspired nanoparticles show improved lung function in idiopathic pulmonary fibrosis, suggesting new treatment options.

Key Points

  • Inhalable nanoparticles effectively improve lung function, reducing fibrosis in a mouse model of IPF.
  • The dual delivery of tetrandrine and pirfenidone showed significant modulation of collagen levels in the lungs.
  • Bioinspired nanocomplex targets collagen deposits and enhances drug delivery, promoting alveolar health.
  • This approach may pave the way for novel therapeutic strategies for idiopathic pulmonary fibrosis.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af570dad7bf08b1eaddc3ehttps://doi.org/10.1002/adhm.202501916
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