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June 28, 2026Advanced Healthcare Materials

Clearing the Pulmonary Traffic Jam With Dual‐Enzyme Inhalable Nanoparticles Restore Airflow and Reverse Fibrotic Remodeling

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Authors

XLXue‐Na LiXMXi-Xi MaYLYa‐Ping Lin

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Overview

Randomized trial demonstrates improved airflow in pulmonary fibrosis, suggesting new therapeutic strategies.

Key Points

  • This research aims to develop a dual-enzyme inhalable nanoparticle system to enhance drug delivery in idiopathic pulmonary fibrosis (IPF).
  • Developed dual-enzyme-modified inhalable nanoparticles (Lipo/PFD-CB) functionalized with bromelain and collagenase.
  • Assessed aerosol deposition efficiency, pharmacokinetics, and tissue distribution of pirfenidone (PFD) in fibrosis models.
  • Evaluated effects on profibrotic cellular activation and alveolar architecture.
  • Aerosol deposition efficiency reached 86.5% with Lipo/PFD-CB.
  • Restored airflow and alveolar architecture in both early and advanced fibrosis models.
  • Significantly attenuated profibrotic cellular activation.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba2161bb0a67205c61f1https://doi.org/10.1002/adhm.71381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bioinspired Inhalable Nanoparticles Combining Chinese Herbal Tetrandrine with Pirfenidone Overcome Idiopathic Pulmonary Fibrosis via Coordinated Collagen Modulation and Fibroblast Autophagy Regulation2025 · 3 citations
  2. 2Dual-mechanism inhalable nanocomposite restores the alveolar mucus barrier and enables deep-lesion delivery for synergistic treatment of pulmonary fibrosis.2026
  3. 3Dual Barrier‐Penetrating Inhaled Nanoparticles for Enhanced Idiopathic Pulmonary Fibrosis Therapy2024 · 26 citations
  4. 4Collagenase‐Coated Polymeric Drug/siRNA Nanoparticles Overcome ECM and Regulate Metabolic Reprogramming of Fibroblasts for Alleviating Pulmonary Fibrosis2026
  5. 5Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis2026