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Retrospective analysis highlights renal function impairment in children with acute pyelonephritis, suggesting targeted therapy may improve outcomes.
Acute pyelonephritis is one of the most common infectious-inflammatory kidney diseases in children. Its course is accompanied by damage to the renal tissue and the pelvic system, which can lead to serious complications, including the outcome in chronic kidney disease. Awareness of the regional features of clinical and laboratory manifestations of this pathology can help a differentiated approach in the diagnosis and therapy of acute pyelonephritis in children. The article presents the results of a retrospective analysis of 64 case histories of children who were hospitalized in the nephrological department of the State Budgetary Healthcare Institution of the Republic of Moldova "Children's Republican Clinical Hospital" in Saransk from 1.01.2022 to 1.08.2024 for acute pyelonephritis. It has been established that acute pyelonephritis in children of the Republic of Mordovia at the present stage is characterized by an increase in body temperature of the pyretic and febrile level, with a predominance of pain syndrome in the lumbar region, a combination of leukocyturia with insignificant hematuria in more than half of the cases, a predominance in the structure of E. coli microflora, impaired renal function by osmotic concentration, and an increase in kidney volume in more than a third of the subjects.
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Раздолькина et al. (2025) studied this question.
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