Axial‐to‐point chirality transfer is an important strategy for the construction of chiral centers, where the axial chiral reagents are mostly limited to atropomerically stable ones. In this work, a Cr(VI)‐catalyzed enantioselective hydroxylative dearomatization (via axial‐to‐point chirality transfer) of axially chiral 2‐naphthols is presented. This transformation proceeds efficiently across a broad range of axially chiral 2‐naphthols, yielding hydroxylative dearomatized products in good yields (up to 85%) with excellent enantioselectivities (up to > 99% ee) and enantiospecificity (up to > 99% es).
Sahoo et al. (Sat,) studied this question.