An Observational Study to Assess the Efficacy of Antibiotics in Sepsis at a Tertiary Care Hospital

Background: Sepsis is a life-threatening condition characterized by organ dysfunction because of dysregulated host response to infection, which continues to challenge clinical management. Objective: To assess the pharmacotherapeutic efficacy of antibiotics in sepsis patients admitted in the hospital. Methodology: This prospective observational study evaluated the clinical effectiveness of antibiotic therapy in 80 adult sepsis patients admitted to a tertiary care centre. The study assessed multiple outcome measures, including trends in inflammatory biomarkers, hemodynamic stabilisation and morality rate, to provide a detailed and insightful evaluation of treatment response. SPSS (version 27) and Microsoft Excel were used for the statistical analysis, and P <0.005 set as significance level. Findings: The results indicated significant improvements in clinical parameters. There was a notable reduction in inflammatory markers, with C- reactive protein (CRP) and procalcitonin levels decreasing significantly (*p* <0.01). Hemodynamic parameters show a remarkable improvement, with increased mean arterial pressure and better lactate clearance (*p* < 0.05). These findings highlight how important it is for the prompt administration of antibiotic therapy in reducing inflammation and bringing back the stability in sepsis patients. However, a high mortality rate of 33.7% was observed in the study. Novelty: This study emphasizes the importance of prompt antibiotic treatment in sepsis by showing significant improvement in SIRS (systemic inflammatory response syndrome) criteria and other inflammatory markers by discharge. It indicates that in order to improve the patient outcome a need for faster diagnostic tools and better antibiotic management is necessary.