The novel approach unites carbene and rearrangement techniques to synthesize complex furans, indicating high yields.
A discovery of the quadruple relay process by merging carbene insertive epoxide ring opening, semipinacol rearrangement, decarbonylation, and Paal–Knorr cyclization reactions to produce highly functionalized furans using chalcone epoxides and diazo compounds has been disclosed for the first time. This unprecedented novel process also produced a variety of α-aryl-β-ketomalonates in high yields with very good functional group tolerance. Interestingly, this novel domino process creates three consecutive bonds (two C–C bonds and one C–O bond) during the furan ring construction.
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Bakthadoss et al. (2025) studied this question.
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