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July 4, 2025Human Molecular GeneticsOpen Access

Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits

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Authors

SGSamuel GhatanJVJard de VriesJPJean‐Baptiste Pingault

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Overview

This observational analysis estimated direct genetic effects on height, BMI, and bone density in children, indicating genetic nurture's limited influence.

Key Points

  • Significant direct genetic effects were found for height, BMI, and bone mineral density in children at ages six, nine, and thirteen.
  • Approximately 71%–77% of BMI variance attributed to direct genetic effects demonstrates a strong genetic influence on the trait.
  • Using polygenic risk scores, the analysis controlled for maternal and paternal influences on children's traits across a diverse cohort.
  • Genetic nurture's impact on anthropometric traits appears limited, highlighting differences from previous findings on other inherited traits.

Cite This Study

Ghatan et al. (2025) studied this question.

synapsesocial.com/papers/68af59d7ad7bf08b1eade6ebhttps://doi.org/10.1093/hmg/ddaf117
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Using parent‐offspring pairs and trios to estimate indirect genetic effects in education2024 · 3 citations
  2. 2The Association Between Parental BMI and Offspring Adiposity: A Genetically Informed Analysis of Trios2024 · 5 citations
  3. 3The association between parental BMI and offspring adiposity: A genetically informed analysis of trios2025
  4. 4Childhood obesity influences mid-to-late life bone health through shared genetic architecture2025
  5. 5Distinct genetic profiles influence body mass index between infancy and adolescence2024