January 1, 2025Brazilian Journal of Medical and Biological ResearchOpen Access

Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models

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Authors

LZLinyu ZhuSun Yat-sen University MGMenger GuoSun Yat-sen University LWLing WangSun Yat-sen University

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Implication

Observational analysis shows trifolirhizin reduces inflammatory responses and keratinocyte hyperproliferation in psoriasis-like models, indicating potential for improved therapy.

Key Points

Trifolirhizin significantly alleviates psoriatic skin lesions by reducing epidermal thickness and inflammation.
In an imiquimod-induced model, trifolirhizin lowered IL-12 levels, improving skin structure and symptoms.
The investigation involved treatment of M5-stimulated HaCaT keratinocytes to measure effects on cell viability and inflammatory markers.
These findings suggest that trifolirhizin’s modulation of the AMPK-mTOR pathway can enhance therapeutic strategies for psoriasis.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68af59ddad7bf08b1eade7db https://doi.org/10.1590/1414-431x2025e14766

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Implication

Observational analysis shows trifolirhizin reduces inflammatory responses and keratinocyte hyperproliferation in psoriasis-like models, indicating potential for improved therapy.

Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models

Discussion

Member takes

Implication

Key Points

Cite This Study

Trifolirhizin improves the hyperproliferation and excessive inflammatory response in human HaCaT keratinocytes and ameliorates skin lesions in psoriasis-like mouse models

Discussion

Member takes

Implication

Key Points

Cite This Study

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