August 16, 2025CureusOpen Access

Complete Recovery From Human Herpesvirus 6 (HHV-6) Encephalomyelitis in an Immunocompetent Adult: A Rare Cause of Paraparesis and Ataxia

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Recovery from HHV-6 encephalomyelitis was achieved with antiviral therapy, demonstrating the possible severity of this virus in adults.
Cerebrospinal fluid analysis showed lymphocytic pleocytosis and elevated protein, confirming HHV-6 diagnosis using Polymerase Chain Reaction.
Treatment with ganciclovir and immunoglobulin led to significant neurological improvement after presenting with severe symptoms.
Highlights the need for awareness of HHV-6 as a cause of encephalomyelitis in previously healthy adults to improve early diagnosis.

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Case report reveals recovery from HHV-6 encephalomyelitis in an immunocompetent adult, suggesting antiviral therapy could improve outcomes.

Jacob et al. (2025) studied this question.

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Case report reveals recovery from HHV-6 encephalomyelitis in an immunocompetent adult, suggesting antiviral therapy could improve outcomes.