A Review on Uses of Combinatorial Chemistry in Drug Discovery

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Review highlights combinatorial chemistry's role in accelerating drug discovery timelines and structural diversity.

Combinatorial chemistry accelerates drug discovery by producing diverse compound libraries, improving efficiency.
Libraries of thousands of compounds can be rapidly synthesized and screened using high-throughput methods.
Integration of solid-phase synthesis techniques revolutionizes lead optimization in pharmaceutical research.
Despite challenges in characterization, ongoing advances in methodologies enhance the impact of combinatorial chemistry.

Pujari et al. (2025) studied this question.

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