Sirenomelia following mifepristone and misoprostol intake: A case report

Sirenomelia is a congenital birth defect that is featured as fused lower limbs, thoracolumbar anomalies, sacrococcygeal agenesis, genitourinary and anorectal atresia and Potter facies. This is a case of sirenomelia in an unsuccessful MTP. A 30-year-old came to emergency at 34 weeks with severe oligohydramnios and FGR. She had MTP pill intake in the first trimester. Her blood sugars were normal. There was no teratogen exposure. She delivered a 1.5kg male baby. In the infant there was fused lower limb, malformed genitalia with absent anogenital opening, rudimentary tail, excessive lanugo, short neck, potter’s facies with prominent epicanthal folds, downward flat nose, receding chin, low set soft dysplastic ears and small slit-like mouth; suggestive of sirenomelia. Maternal diabetes is the most established etiological factor. Cocaine abuse, tobacco, misoprostol, trimethoprim, phenobarbital and carbamazepine use have reported cases of sirenomelia. Our case had MTP pill intake. Unregulated over-the-counter intake of MTP drugs should be discouraged