Unlocking the Multifunctional Therapeutic Potential of Manassantin: A Lignan-Derived Scaffold

Manassantin, a dineolignan, is a natural compound that has gained significant attention due to its diverse pharmacological properties, including anti-inflammatory, anticancer, neuroprotective, and antimicrobial effects. Its unique polyphenolic scaffold offers a versatile platform for drug development, enabling targeted therapeutic applications. This review explores the molecular mechanisms underlying the bioactivity of manassantin with a focus on its role in modulating key cellular pathways, including NF-κB, MAPK, JAK/STAT, oxidative stress, apoptosis, and inflammatory signaling. Furthermore, it highlights recent advancements in structural modifications aimed at enhancing the pharmacokinetic and pharmacodynamic properties of this compound. By unlocking the full therapeutic potential of manassantin, this study paves the way for its future development as a multifunctional therapeutic agent.