January 1, 2025Chemical CommunicationsOpen Access

Monitoring Nucleoside Metabolism in Living Cells with a Nucleobase Analogue via Fluorescence Lifetime Imaging

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Nucleoside metabolism can be effectively monitored in living cells using a new fluorescent analogue, 2CNqA.
Key findings indicate that fluorescence lifetime imaging is effective for observing RNA dynamics.
This analysis adopted fluorescence lifetime imaging to visualize nucleoside metabolism in real-time inside cells.
Further research could enable improved RNA monitoring techniques, enhancing understanding of cellular processes.

Implication

Demonstration shows nucleoside metabolism can be observed in living cells using fluorescence imaging, highlighting a novel analogue approach.

Abstract

To overcome challenges in fluorescence labelling of RNA inside living cells we have recently introduced a direct approach using the fluorescent nucleobase analogue 2CNqA. Here we demonstrate its potential for...

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Cite This Study

Pfeiffer et al. (2025) studied this question.

synapsesocial.com/papers/68af5bc1ad7bf08b1eadfdda https://doi.org/10.1039/d5cc03959b

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Implication

Demonstration shows nucleoside metabolism can be observed in living cells using fluorescence imaging, highlighting a novel analogue approach.

Monitoring Nucleoside Metabolism in Living Cells with a Nucleobase Analogue via Fluorescence Lifetime Imaging

Key Points

Implication

Abstract

Discussion

Cite This Study

Monitoring Nucleoside Metabolism in Living Cells with a Nucleobase Analogue via Fluorescence Lifetime Imaging

Key Points

Implication

Abstract

Discussion

Cite This Study

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