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August 25, 2025Frontiers in HematologyOpen Access

A perfect storm: the deadly intersection of sickle cell disease and COVID-19

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This review reveals significant immunopathological interactions between sickle cell disease and COVID-19, suggesting urgent research needs.

The intersection of sickle cell disease and COVID-19 reveals critical knowledge gaps, especially in understanding inflammatory markers that affect patient outcomes during the pandemic.
Pathophysiological mechanisms such as cytokine storms and autoimmune responses illustrate the dangers faced by sickle cell disease patients with COVID-19.
The investigation includes hyperhaemolysis syndrome and avascular necrosis as serious complications stemming from the combined effects of both conditions.
Understanding these connections is vital for developing targeted therapeutic interventions for patients with sickle cell disease, particularly in areas affected by both diseases.

Martí-Carvajal et al. (2025) studied this question.

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August 25, 2025Frontiers in HematologyOpen Access

View Full Paper

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Authors

This review reveals significant immunopathological interactions between sickle cell disease and COVID-19, suggesting urgent research needs.

The intersection of sickle cell disease and COVID-19 reveals critical knowledge gaps, especially in understanding inflammatory markers that affect patient outcomes during the pandemic.
Pathophysiological mechanisms such as cytokine storms and autoimmune responses illustrate the dangers faced by sickle cell disease patients with COVID-19.
The investigation includes hyperhaemolysis syndrome and avascular necrosis as serious complications stemming from the combined effects of both conditions.
Understanding these connections is vital for developing targeted therapeutic interventions for patients with sickle cell disease, particularly in areas affected by both diseases.

Martí-Carvajal et al. (2025) studied this question.

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