Lanthanide-based UCNPs: Toxicity evaluation and interaction of ultrasmall core vs. core-shell nanoparticles with cells

Mykhailo Nahorniak; Daniel Horák; Miroslav Šlouf; Miloš Steinhart; Oleksandr Shapoval; Hana Engstová; Petr Ježek

doi:10.1039/d5ma00542f

January 1, 2025Materials AdvancesOpen Access

Lanthanide-based UCNPs: Toxicity evaluation and interaction of ultrasmall core vs. core-shell nanoparticles with cells

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Key Points

Ultrasmall lanthanide-based UCNPs demonstrated varying toxicity levels depending on their structure and composition, affecting cellular interactions with cells.
The research highlights that core and core-shell nanoparticles display different behaviors in toxicity evaluations, which is crucial for their biomedical use.
Assessment across various water content levels in the polymerization mixture showed significant differences in nanoparticle properties and toxicity.
Findings suggest careful consideration of nanoparticle design is needed to ensure safety in future biomedical applications and therapies.

Implication

Toxicity evaluation reveals interactions of ultrasmall core and core-shell UCNPs in cells, indicating safety concerns for biomedical applications.

Abstract

We describe a new concept for preparation of ultrasmall NaYF 4 :Yb,Er upconversion nanoparticles (UCNPs) with a diameter of 7 nm, depending on the amount of water added in the polymerization mixture,...

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Cite This Study

Nahorniak et al. (2025) studied this question.

synapsesocial.com/papers/68af5d63ad7bf08b1eae06d6 https://doi.org/10.1039/d5ma00542f

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Lanthanide-based UCNPs: Toxicity evaluation and interaction of ultrasmall core vs. core-shell nanoparticles with cells

Key Points

Implication

Abstract

Discussion

Cite This Study

Lanthanide-based UCNPs: Toxicity evaluation and interaction of ultrasmall core vs. core-shell nanoparticles with cells

Key Points

Implication

Abstract

Discussion

Cite This Study

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