Figure 3 from Patterns of HER2 Expression in Metastatic Prostate and Urothelial Cancers: Implications for HER2-Targeted Therapies

Hyun Jung Lee; Roman Gulati; Erolcan Sayar; Radhika A. Patel; Pushpa Itagi; Helen Richards; Thomas Persse; Sonali Arora; Ilsa M. Coleman; Mohamed Adil; Samantha L. Schuster; Farinaz Shokri; Jonathan L. Wright; Evan Y. Yu; Lawrence D. True; Meagan Chambers; Jessica E. Hawley; Heather H. Cheng; Michael T. Schweizer; Petros Grivas; Peter S. Nelson; Bruce Montgomery; Andrew C. Hsieh; Funda Vakar‐Lopez; Colm Morrissey; Hung‐Ming Lam; Gavin Ha; Maria Tretiakova; Michael C. Haffner; Ruben Raychaudhuri

doi:10.1158/2767-9764.29978432

Key Points

Higher HER2 scores correlate with increased protein expression of cell surface antigens in prostate cancer, enhancing treatment pathways.
The analysis shows distinct patterns of HER2 expression in prostate cancer versus urothelial cancer, indicating varied responses to therapies.
Utilizing immunohistochemistry (IHC), the study evaluates protein expression levels in cancerous tissues, providing a basis for therapeutic strategies.
Further research is needed to establish the efficacy of HER2-targeted therapies across different cancer types, especially in metastatic settings.

Implication

Analysis reveals the correlation of HER2 scores with key cell surface antigens in prostate and urothelial cancers, suggesting potential for targeted therapies.

Abstract

A and B, Box plots indicating the relationship between HER2 score with protein expression of key cell surface antigens as measured by IHC in (A) prostate cancer and (B) urothelial cancer.

Discussion

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Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68af5d63ad7bf08b1eae06e6 https://doi.org/10.1158/2767-9764.29978432

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Figure 3 from Patterns of HER2 Expression in Metastatic Prostate and Urothelial Cancers: Implications for HER2-Targeted Therapies

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure 3 from Patterns of HER2 Expression in Metastatic Prostate and Urothelial Cancers: Implications for HER2-Targeted Therapies

Key Points

Implication

Abstract

Discussion

Cite This Study

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